Just when the 49ers show up set to invite back their beginning quarterback, another key player has actually gone down with an injury.

Left tackle (elbow/ankle) did not join San Francisco's practice for a 3rd straight day as well as draws a skeptical classification, while quarterback (calf) had no designation and also novice signal-caller (knee) is out, as expected. Garoppolo will certainly begin when the 49ers host the Indianapolis Colts on Sunday night.

Williams has been a rock for the 49ers, safeguarding the blind side of Garoppolo and Lance. If offensive line injuries matter much more because of the quarterback they're securing, maybe none is more vital than the males charged with obstructing for Garoppolo, the often-injured signal-caller whose failure to stay on the area motivated San Francisco to prepare a reputable ability and also ultimate follower.

Williams is the 49ers' ideal player in charge of shielding Garoppolo. Last season, he was the most effective tackle in the NFL, per Pro Football Emphasis. His absence would make the return of Garoppolo a more nervous event than if Williams had the ability to play.

Garoppolo will return after missing out on Week 5 versus the Cardinals. Lance began in Garoppolo's place in the loss to Arizona, but won't be readily available Sunday.

The 49ers' fanbase will maintain its cumulative fingers crossed that novice can show to a be a functional substitute if Williams can not go.